Enhancement of Swarming and Inhibition of Prodigiosin in Serratia marcescens by Glyceryl Trinitrate

Introduction:Serratia marcescens is a gram-negative pathogen of many species. Its pathogenicity and survival are linked to its capacity build biofilms as well strong inherent resistance antimicrobials cleaning agents. Objectives: To analyse the impact glyceryl trinitrate (GTN) on gene expression QS-related genes (rssB, rsmA,and pigP) S. marcescens. Methodology: The broth microdilution technique estimated bactericidal effectiveness trinitrate. presence rssB, pigP in isolates was detected using PCR. qRT-PCR used assess effect GTN pigPgene expression. Results: results demonstrated that has no growth. Furthermore, were located all their downregulated due presence. Conclusion: can act promising anti-quorum sensing agent reference